Premier League Betting Guide for Matchweek 21

Manchester United have been energized since the firing of Jose Mourinho. Should we expect the Red Devils' run to continue?

Matchweek 21 provides some exciting matchups, including a monumental clash between Manchester City and Liverpool.

Using FanDuel Sportsbook as the source for lines, let's take a look at some bets you should zero in on this week.

Please note that lines are subject to change after this article is published, which impacts betting advice. All betting lines were taken from Paddy Power, and you can check here to see their most updated numbers.

Newcastle vs Manchester United

Manchester United to win -170

Manchester United seem to be energized by their new manager, Ole Gunnar Solskjær. Since hiring Solskjær, United have won three straight league matches by a combined score of 12-3, and they should be able to continue that strong run against 15th-place Newcastle on Wednesday.

Newcastle have started the season with a 4-6-10 record, including a 1-2-8 mark against teams in the top half of the table. Newcastle have earned zero points against the top eight, and with United rolling, it's hard to expect much from the Magpies in this game.

Huddersfield vs Burnley

Under 2.5 Goals -166

Under 1.5 Goals +186

Huddersfield have played six games against the bottom seven and only one of those games has seen more than two total goals. For Burnley, the numbers are not quite as stark, but three of their six games against the bottom seven have also finished with less than two total goals.

Unsurprisingly, Burnley rank last in the league in shots per game (8.9) while Huddersfield are not far behind, sitting 16th in shots (11.4). This has the makings of a low-scoring game, with under 2.5 seeming very likely and under 1.5 very possible, as well.

Everton vs Leicester

Leicester +1 (no push) -125

You can get surprisingly good odds on Leicester in this game despite the fact that the Foxes are ahead of Everton in the standings. Leicester are also one spot ahead of Everton in’s team rankings, so it seems clear that these teams are evenly matched, with Leicester perhaps being very slightly superior.

Yes, Everton own home-field advantage in this game, but they are far from invincible at Goodison Park (5-3-2) while Leicester are no slouch away from home (4-2-4). In what should be an evenly-matched fixture, it's safe to expect Leicester to be able to at least earn a draw.