What It Means:

Wilson was listed as questionable headed into Sunday's game against the New England Patriots with a calf strain, but that didn't stop him from putting up 113 yards on the ground and 3 touchdowns. Unfortunately, he joined both Raheem Mostert and Tevin Coleman as yet another injured 49ers running back by the end of the game. He'll miss at least the next 3 games while on the injured reserve.

The 49ers have one of the most dominant running games in the league, and can seemingly turn anyone into a fantasy-relevant player at a whim. At this point, the team is left with just Jerick McKinnon and JaMycal Hasty at the position, which narrows down the possibilities significantly for fantasy football purposes.