What It Means:

Mostert has operated as the 49ers' clear lead back whenever he has been healthy, but he has struggled to stay healthy in 2020. This ankle sprain will likely result in a trip to the injured reserve and could cause Mostert to miss 6-8 weeks.

When Mostert missed time earlier this season, Jerick McKinnon looked like the team's lead back, even playing on 92% of the team's offensive snaps despite his own struggles with a knee injury over the past two seasons. McKinnon is likely to see a huge workload going forward while working alongside Jamycal Hasty.