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49ers' Brandon Aiyuk coming off COVID-19 list

The San Francisco 49ers are activating wide receiver Brandon Aiyuk from the reserve/COVID-19 list Tuesday.

What It Means:

Aiyuk will be available for Week 13 versus the Buffalo Bills after missing Sunday's win over the Los Angeles Rams. He had drawn 7-plus targets, caught at least 6 passes, and recorded 75 or more receiving yards in three straight games before landing on the reserve list. Aiyuk's return could potentially cut into Deebo Samuel's workload but both receivers are capable of providing fantasy value while sharing the field in Kyle Shanahan's offense.

Aiyuk is averaging 16.6 FanDuel points over his last three games and he's had a snap share above 70.0 percent in every game he's played this season. The Bills have the No. 19 pass defense in numberFire's advanced efficiency rankings.