What It Means:

Williams is still in concussion protocol after sustaining a concussion in Week 4. LeSean McCoy is expected to miss Week 5, meaning that if Williams can't go, the Boobie Dixon will likely start.

The Bills will be facing a Tennessee Titans defense that currently ranks 25th in Adjusted Defensive Rushing Net Expected Points (NEP) per play. This means there will be opportunity for whoever carries the bulk of the load. Additionally, the Bills as a team rank fourth in Adjusted Rushing NEP per play, so it may be worth a roll of the dice on Dixon if Williams is out.