Premier League Betting Guide for Matchweek 22

Arsenal have been dominant this season against teams outside of the top six. Can they continue that run against West Ham?

Manchester City defeated Liverpool last week to keep the title race interesting. Can Tottenham step up at home against Manchester United and prove themselves as legitimate title contenders? Which other matches should you zero in on this week?

Using FanDuel Sportsbook as the source for lines, let's take a look at some bets you should zero in on this week.

Please note that lines are subject to change after this article is published, which impacts betting advice. All betting lines were taken from Paddy Power, and you cancheck here to see their most updated numbers.

West Ham vs. Arsenal

Arsenal to win +100

The Gunners are currently sitting in fifth place with 41 points, 13 points ahead of West Ham. Arsenal have dominated opponents outside of the top six, boasting an 11W-3D-1L record in the split, and they have already defeated West Ham, 3-1, earlier this season.

On the flip side, West Ham do own home-field advantage, although they are a mediocre side at home (4-2-5; -2 goal difference). The Hammers are 1-1-4 against the top six so far this season, so the matchup seems to favor Unai Emery’s side.

Leicester vs. Southampton

Leicester to win -105

Leicester City are surprisingly only small favorites considering they own home-field advantage and have played at a much higher level than Southampton so far this season. The Foxes are 14 points higher than the Saints in the league table and own a 19-goal advantage in terms of goal difference.

Southampton are a dreadful 1-3-9 against the top-10 teams in the league this season, so they have not been a threat to win against quality competition. The talent will likely be too much for the Saints to overcome this weekend.

Tottenham vs. Manchester United

Tottenham to win +110

Manchester United have been off to an impressive start to the Ole Gunnar Solskjaer era as they have won four consecutive league games, all by more than one goal. However, United’s success so far has been exclusively against bottom-half teams (12th-ranked Bournemouth is their best win since the managerial change). Spurs will provide a much more difficult challenge for United given their impressive 16-0-5 record and third-place standing in the table.

Despite United’s hot streak, it is hard to overlook that Spurs remain 10 points ahead of United and boast a goal difference that is 14 goals superior. Spurs also own a substantial edge in’s team rankings (6.92 vs 6.79), and it is hard to overlook the better play Tottenham have demonstrated for the duration of this season. Mauricio Pochettino’s side should be able to earn the full three points in this match.