With the fixtures bunched so closely together, there has been more lineup juggling and squad rotation among teams. Much of that is due to injuries piling up, and that should be the case again this weekend.

Marcus Rashford ($11,000) was fit enough to be on the bench on Wednesday, but Romelu Lukaku ($12,500) scored twice for Manchester United in Rashford's absence. Attackers Raheem Sterling ($11,000) and Marko Arnautovic ($10,500) were not in the starting lineup for their respective clubs, either, on Wednesday.

Defensively, West Ham gave a start to 19-year-old Ben Johnson. He was replaced just after the hour mark in the match against Manchester City, which may not bode well for his chances to start again on Saturday.

Southampton changed out much of their back line and escaped with a 2-0 victory. It was a big win that moved them out of the relegation zone, so the changes from Wednesday may carry over to Saturday.

The busy schedule means more managers, especially those with commitments outside of Premier League play, have to get creative. It's always important to consult the starting lineups about an hour before kickoff, but it's even more crucial this weekend.