This article is geared towards FanDuel's main slate, which begins at 2:45 p.m. EST Wednesday and features six matches. There are six matches on deck for Wednesday, and the marquee match on the slate sees United host Arsenal, with the Red Devils a slight +140 favorite on FanDuel’s Sportsbook, which puts their implied win probability at 41.7%.

As with any DFS sport, it is imperative to have your players, especially the high-priced studs, live up to their price tag. When investing in any player, it is important to determine who will likely contribute in FanDuel's emphasized areas (goals, assists, and shots on target). It's also just as crucial not to overspend on players in bad matchups.

We should try to take advantage of the teams -- and players -- who play especially well either home or away, while also looking at oddsmakers' favorites and over/under totals. With the busy Holiday season upon us, DFS players, as always, should check out injury reports and confirmed starting XI's when they become available since some players may be rested.

Let's take a look at four players across the entire pitch who should be avoided.