Indianapolis Colts quarterback Andrew Luck (shoulder) has been ruled out for Week 2's matchup with the Arizona Cardinals.
Head coach Chuck Pagano hasn't fully ruled out Luck's returning to practice this week, but the decision on his status for Week 2's game coming this early is a sign that he's probably a long shot to play in Week 3 as well, and could still miss a significant amount of time. There's no word on Week 2's starter yet, after Scott Tolzien started in Week 1 but struggled and was benched for Jacoby Brissett.
numberFire's models currently project Luck for 3064.4 yards, 23.5 touchdowns and 10.8 interceptions on 431.9 pass attempts this season, but look for those marks to decrease significantly while it looks like he's going to miss extended time.
Source: Rotoworld.com