What It Means:

McCoy suffered a setback at practice and won't be able to play on Sunday. With a history of hamstring issues, the running back's long-term status is in doubt. The Bills have a bye in Week 10, but hopefully McCoy returns prior to then. Mike Gillislee is the leader in Buffalo's backfield until further notice. He's a solid RB2 option in Week 7 versus the Miami Dolphins.

On 17 attempts this season, Gillislee is averaging 0.42 Rushing Net Expected Points per play. That is the best mark in the league among all backs with at least 10 carries.