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49ers' Elijah Mitchell (knee) out again for Week 16

San Francisco 49ers running back Elijah Mitchell (knee) has been ruled out of Week 16's game against the Tennessee Titans.

What It Means:

Mitchell has been downgraded to out and will remain sidelined for Thursday's showdown with the Titans. Despite some optimism around Mitchell's recovery, he will not be available to face the Titans. Look for Jeff Wilson to continue to see an increased workload while Mitchell is out.

The 49ers are 3.5-point favorites over the Titans on Thursday. Their implied team total of 23.75 points is the twelfth-highest team total on Week 16's 'Thu-Mon' slate, according to numberFire's DFS Heat Map.