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49ers not optimistic Brandon Aiyuk (COVID-19) will be available for Week 12

San Francisco 49ers wide receiver Brandon Aiyuk (COVID-19) is expected to remain out for Week 12's game against the Los Angeles Rams.

What It Means:

Aiyuk was placed on the reserve/COVID-19 list a week ago and appears unlikely to be cleared in time to face the Rams in Week 12. Deebo Samuel (hamstring) is expected back and would return to a role as the 49ers' top wide receiver with Aiyuk sidelined.

The 49ers are 6.0-point underdogs against the Rams in Week 12. Their implied team total of 19.25 points is the fourth-lowest team total on Sunday's main slate, according to numberFire's DFS Heat Map.