Heading into Week 4 and even further into the season, we're starting to have more data. With that data, we can draw better conclusions.

The Week 4 slate has a few high-scoring games that you should get some exposure in, with Green Bay at San Francisco paving the way with a 48.5-point total over/under. Both the Colts and the Seahawks are 10-point home favorites at home against the Jaguars and Lions, respectively. With only 5 of the 15 games expected to be within three points per Vegas spreads, this could be a week with a ton of points at the running backs position as several blowouts are projected.

As a rule of thumb, you want your players to hit three times their value; that is to say for each $1,000 in salary, we want that player to achieve three fantasy points (i.e. If customizable lineups by inputting your players and seeing what our projections offer for the week. There's even an optimization function that'll use our algorithms to help fill out the rest of your daily lineup and give you the best chance of succeeding on game day.

Using Vegas spreads and totals, our Net Expected Points (NEP) metric, and some daily fantasy gamesmanship, we'll take a look at which players you should target this weekend.

As a reminder, the New York Jets and Miami Dolphins will play in London this week at 9:30, so if you're looking to target any players in this game, keep this in mind. Also, the Patriots and Titans are on a bye week.