Before falling to the Pittsburgh Steelers in the divisional round of the AFC playoffs, Peyton Manning led his Indianapolis Colts to a 14-2 record in the regular season. The Colts' signal-caller earned a quarterback rating of 104.1 on a league-leading 8.03 ANY/A.

All total, Manning threw for 3,747 yards and 28 touchdowns to just 10 picks on a completion percentage of 67.33%. He was named First-Team All-Pro for the third consecutive season.